Journal Articles


M. Planchestainer, M.L. Contente, J. Cassidy, F. Molinari, L. Tamborini, F. Paradisi “Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongataGreen Chemistry, 2017, 19, 372-375

M.L. Contente, M. Planchestainer, F. Molinari, L. Tamborini, F. Paradisi “Stereoelectronic effects in the reaction of aromatic substrates catalysed by Halomonas elongata transaminase and its mutants” Organic and Biomolecular Chemistry 2016, 16, 9306-9311

B. Kutasy, F. Friedmacher, L. Pes, D. Coyle, T. Doi F. Paradisi, P. Puri “Antenatal Retinoic Acid Administration Increases Trophoblastic Retinol-Binding Protein Dependent Retinol Transport in the Nitrofen Model of Congenital Diaphragmatic Hernia” Pediatric Resaearch 2016, 76, 614-620

L. Cerioli, M. Planchestainer, J. Cassidy, D. Tessaro, F. Paradisi “Characterization of a novel amine transaminase from Halomonas elongataJournal of Molecular Catalysis B: Enzymatic 2015, 120, 141–150

H. Takahashi, B. Kutasy, L. Pes, F. Paradisi, P. Puri “Decidual β-carotene-15,15’-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia” Paediatric Surgery International2015, 31, 37-43

K. Pandurangan, J. A. Kitchen, S. Blasco, F. Paradisi, T. Gunnlaugsson “Supramolecular pyridyl urea gels as soft matter with antibacterial properties against MRSA and/or E. coliChem Commun 2014, 50, 10819-10822

B. Kutasy, L. Pes, F. Friedmacher, F. Paradisi, P. Puri “Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia” Paediatric Surgery International 2014, 30, 1017-1022

B. Kutasy, F. Friedmacher, L. Pes, F. Paradisi, P. Puri “Increased uptake of dietary retinoids at the maternal-fetal barrier in the nitrofen model of congenital diaphragmatic hernia” Journal of Paediatric Surgery 2014, 49, 866-870

D. Alsafadi, F. Paradisi “Covalent immobilization of alcohol dehydrogenase (ADH2) from Haloferax volcanii: how to maximize activity and optimize performance of halophilic enzymes” Molecular Biotechnology 2014, 56, 240-247

W. Streciwilk, J. Cassidy, F. Hackenberg, H. Müller-Bunz, F. Paradisi, M. Tacke “Synthesis, cytotoxic and antibacterial studies of p-benzyl-substituted NHC-silver(I) acetate compounds derived from 4,5-di-p-diisopropylphenyl- or 4,5-di-p-chlorophenyl-1H-imidazole” Journal of Organometallic Chemistry 2014, 749, 88-99

K. Robertson, C. Murphy, F. Paradisi “The Synthesis and Biological Testing of Bacilysin Analogues” Amino Acids2013, 45, 1157-1168

A. Liliensiek, J. Cassidy, G. Gucciardo, C. Whitely, F. Paradisi “Heterologous overexpression, purification and characterisation of an alcohol dehydrogenase (ADH2) from Halobacterium sp. NRC-1” Molecular Biotechnology2013, 55, 143-149

D. Quaglia, M. Pori, P. Galletti, E. Emer, F. Paradisi and D. Giacomini “His-tagged Horse Liver Alcohol Dehydrogenase: Immobilization and application in the bio-based enantioselective synthesis of (S)-arylpropanols” Process Biochemistry 2013, 48, 810-818

E. O’Reilly, L. Pes, Y. Ortin, H. Müller-Bunz , F. Paradisi “Synthesis of a conformationally constrained δ-amino acid building block” Amino Acids 2013, 44, 511-518

D. Alsafadi, F. Paradisi “Effect of organic solvents on the activity and stability of halophilic alcohol dehydrogenase (ADH2) from Haloferax volcaniiExtremophiles 2013, 17, 115-122

F. Hackenberg, G. Lally, H. Müller-Bunz, F. Paradisi, D. Quaglia, W. Streciwilk, M. TackeSynthesis and biological evaluation of N-heterocyclic carbene-silver(I) acetate complexes derived from 4,5-ditolyl-imidazole” Inorganica Chimica Acta 2013, 395, 135-144

L. Timpson, A. Liliensiek, D. Alsafadi, M. A. Sharkey, S. Liddell, T. Allers, F. Paradisi “A comparison of two novel alcohol dehydrogenase enzymes (ADH1 and ADH2) from the extreme halophile Haloferax volcaniiApplied Microbiology and Biotechnology  2013, 97, 195-203

M. A. Sharkey, J. P. O’Gara, S. V. Gordon , F. Hackenberg, C. Healy, F. Paradisi, S. Patil, B. Schaible,  M. Tacke “Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3” Antibiotics2012, 1, 25-28

D. Quaglia, J. Irwin, F. Paradisi “Horse Liver Alcohol Dehydrogenase: new perspectives for an old enzyme”Molecular Biotechnology  2012, 52, 244-250

F. Hackenberg, G. Lally, H. Müller-Bunz, F. Paradisi, D. Quaglia, W. Streciwilk, M. Tacke Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes – synthesis and biological evaluation Journal of Organometallic Chemistry 2012, 717, 123-134

D. Balducci, P. A. Conway, G. Sapuppo, H. Müller-Bunz, F. Paradisi “Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids” Tetrahedron 2012, 68, 7374-7379

E. Lestini, K. Robertson, C.D. Murphy, F. Paradisi “An alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B” Synthetic Communication 2012, 42,1864-1876 

F. Hackenberg, A. Deally, G. Lally, Sina Malenke,, H. Müller-Bunz, F. Paradisi, S. Patil, D. Quaglia,   M. Tacke “Novel non-symmetrically p-benzyl-substituted (benz)imidazole N-heterocyclic carbene-silver(I) acetate complexes – synthesis and biological evaluation” Int. Journal of Inorganic Chemistry 2012, vol. 2012, Article ID 121540, 13 pages.

L. Timpson, D. Alsafadi, C. Mac Donnchadha, S. Liddell, M. A. Sharkey, F. Paradisi “Characterization of alcohol dehydrogenase (ADH12) from Haloarcula marismortui, an extreme halophile from the Dead SeaExtremophiles 2012, 16, 57-66

S. Devereux , P. S. Shuttleworth, D. J. Macquarrie, and F. Paradisi “Isolation and Characterisation of Recovered Starch from Industrial Wastewater” Journal of Polymers and the Environment 2011, 19, 971-979

K. Pandurangan, K. D. Murnaghan, A. Walshe, H. Müller-Bunz, F. Paradisi and G. G. Morgan Design, Synthesis and Structure of Novel para-quinones and their Antibacterial Activity” Chemical Biology and Drug Design 2011,78, 787-799

A. O’Sullivan,  D. Balducci, F. Paradisi,  K. Cashman, M. J. Gibney, L. Brennan Effects of supplementation with vitamin D3 on glucose production pathways in human subjects” Molecular Nutrition & Food Research 2011, 55, 1018–1025

S. Patil, A. Deally, B. Gleeson, F. Hackenberg, H. Müller-Bunz, F. Paradisi, M. Tacke “Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Non-Symmetrically p-Nitrobenzyl-Substituted N-Heterocyclic Carbene- Silver(I) Acetate Complexes” Journal of Inorganic and General Chemistry 2011, 637, 386–396

S. Patil, A. Deally, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke.”Novel Benzyl-Substituted N-Heterocyclic Carbene–Silver Acetate Complexes: Synthesis, Cytotoxicity and Antibacterial Studies” Metallomics 2011, 3, 74-88

S. Patil, K. Dietrich, Deally, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke “Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Non-Symmetrically 4-(Methoxycarbonyl)benzyl-Substituted N-Heterocyclic Carbene-Silver Acetate Complexes” Helvetica Chimica Acta 2010, 93, 2347-2364

D. O. Frimannsson, M. Grossi, J. Murtagh, F. Paradisi and D. F. O´Shea “Light Induced Anti-microbial Properties of a Brominated BF2 – Chelated Tetraarylazadipyrromethene Photosensitizer” J. Med. Chem. 2010, 53, 7337-7343

S. Patil, J. Claffey, B. Gleeson, H. Müller-Bunz, F. Paradisi, M. Tacke “Synthesis, Cytotoxicity and Antibacterial Studies of Symmetrically and Non-Symmetrically Benzyl- or p- Cyanobenzyl-Substituted N-Heterocyclic Carbene-Silver Complexes” Applied. Organometallic Chemistry 2010, 24, 781–793

K. Pandurangan, S. Gallagher, G. G. Morgan, H. Müller-Bunz, F. Paradisi “Structure and Anti-Microbial Activity of the Silver(I) Complex of 2-Aminophenoxazine-3-one” Metallomics 2010, 2, 530-534 (Front cover)

E. O’Reilly, D. Balducci, F. Paradisi A stereoselective synthesis of α-deuterium labelled (S)-α-amino acids” Aminoacids 2010, 39, 849-858

E. O’Reilly, L. Pes, F. Paradisi “From amines to diketopiperazines: a one-pot approach” Tetrahedron Lett. 2010,51, 1696-1697

S. Patil, J. Claffey, A. Deally, M. Hogan, B. Gleeson, L. M. Menéndez Méndez, H. Müller-Bunz, F. Paradisi, D. Wallis, M. Tacke “Synthesis, Cytotoxicity and Antibacterial Studies of p-Methoxybenzyl-Substituted and Benzyl-Substituted N-Heterocyclic Carbene-Silver Complexes” Eur. J. Inorg. Chem. 2010, 1020-1031

S. Moran, K. Robertson, F. Paradisi, D. Rai, C. Murphy Production of lipopeptides in Bacillus sp. CS93 isolated from Pozol” FEMS Letters 2010, 304, 69-73P.A. Conway, K. Devine, F. Paradisi “A simple and efficient method for the synthesis of Erlenmeyer azlactonesTetrahedron 2009, 65, 2935-2938

E.O’Reilly, E. Lestini, D. Balducci, F. Paradisi One-step diketopiperazine synthesis using phase transfer catalysis” Tetrahedron Lett. 2009, 50, 1748-1750

B. Gleeson, J. Claffey, D. Ertler, M. Hogan, H. Müller-Bunz, F. Paradisi, D. Wallis, M. Tacke “Novel organotin antibacterial and anticancer drugs  Polyhedron 2008, 27, 3619-3624

F. Paradisi, P.A. Conway, A. Maguire, P. C. Engel Engineered dehydrogenase biocatalysts for non-natural amino acids: efficient isolation of the D-enantiomer from racemic mixtures Organic and Biomolecular Chemistry 2008, 6, 3611-3615

D. Giacomini, P. Galletti, A. Quintavalla, G. Gucciardo, F. Paradisi Highly Efficient Asymmetric Reduction of Arylpropionic-aldehydes by Horse Liver Alcohol-Dehydrogenase Through Dynamic Kinetic Resolution” Chem.Commun. 2007, 4038-4040 (Highlighted as a HOT TOPIC)

N. Nakazawa, S. Montedonico, H. Takayasu, F. Paradisi, Prem Puri “Disturbance of retinol transportation causes Nitrofen induced hypoplastic lung” J. Pediatr. Surg., 2007, 42, 345-349

F. Paradisi previous work:

F. Paradisi, S. Collins, A. R. Maguire, P. C. Engel “Phenylalanine dehydrogenase mutants: Efficient biocatalysts for synthesis of non-natural phenylalanine derivatives” J. Biotechnol., 2007,128, 408-411

E. Faulkner, M. Barret, S. Okor, F. Paradisi, P. C. Engel, B. Glennon “The use of fed batch cultivation for achieving high cell densities for the pilot scale production of a recombinant protein (Phenylalanine dehydrogenase) in Escherichia coli” Biotechnology Progress 2006, 22, 889-897

G. Cainelli, P. Engel, P.Galletti, D. Giacomini, A. Gualandi, F. Paradisi Engineered Phenylalanine Dehydrogenase in Organic Solvents: Homogeneous and Biphasic Enzymatic Reaction Organic and Biomolecular Chemistry,2005, 3, 4316–4320

F. Paradisi, R. Woolfson, K.F. Geoghegan, P.C. Engel “Identification of the Residue Responsible for Catalysing Regeneration of Activity in the Inactive Glutamate Dehydrogenase Mutant D165N” FEBS letters, 2005, 579, 2830-2832

F. Paradisi, J.L.E. Dean, K.F. Geoghegan, P.C. Engel “Spontaneous chemical reversion of an active site mutation: Deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase” Biochemistry, 2005, 44, 3636-3643

P. Busca, F. Paradisi, E. Moynihan, A. R. Maguire, P. C. Engel “Enantioselective Synthesis of Non-natural Amino Acids using Phenylalanine Dehydrogenases Modified by Site-directed Mutagenesis Organic and Biomolecular Chemistry 2004, 2, 2684 – 2691

N. E. Batoux, F. Paradisi, P. C. Engel, M. E. Migaud “Novel Nicotinamide Adenine Dinucleotide analogues as selective inhibitors of  NAD+-dependent enzymes  Tetrahedron 2004, 60, 6609-6617

A. Arcelli, F. Paradisi, G. Porzi, S. Rinaldi, S. Sandri “Acid Hydrolysis of the Ether Bond Assisted by the Neighbouring Amide Group: Effects Induced by Salts and by Structural Changes. Part 6” Journal of Chemical Research (Synopses) 2002, 5, 501-518

F. Paradisi, F. Piccinelli, G. Porzi, S. Sandri “Enantioselective Synthesis of 2,6-diaminopimelic acid derivatives. Part 3 Tetrahedron: Asymmetry 2002, 13, 497-502

F. Paradisi, G. Porzi, S. Sandri “A new stereocontrolled synthesis of uncommon tripeptides derived from (2,6)-diaminopimelic acid (2,6-DAP)” Tetrahedron: Asymmetry 2001, 12, 3319-3324

G. Cainelli, D. Giacomini, P. Galletti, P. Orioli, F. Paradisi “Diastereofacial Selectivity of O-protected-a – Hydroxy Aldehydes: Temperature and Solvent effect Eur. J. Org. Chem. 2000, 3619-3626

F. Paradisi, G. Porzi, S. Rinaldi, S. Sandri “Stereoselective synthesis of a,a’-diaminodicarboxylic acids. Part 2” Tetrahedron: Asymmetry 2000, 11, 4617-4622

F. Paradisi, G. Porzi, S. Rinaldi, S. Sandri “A simple asymmetric synthesis of (+)- and (-) -2,6-diaminopimelic acids Tetrahedron: Asymmetry 2000, 11, 1259-1262

P. Di Felice, M. Maestri, F. Paradisi, G. Porzi, S. Sandri “Highly stereocontrolled boron-mediated synthesis of β-hydroxy-α-aminoacids and dipeptides. Part 2” Tetrahedron: Asymmetry 1999, 10, 4709-4714.


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