Applied Microbiology and Biotechnology (2019): “Haloferax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems”
Very nice to see that Haloferax can indeed catalyse reactions as whole cell organism and be immobilised for reuse too! Great collaboration with our colleague Thorsten Allers here in Nottingham and well done Risat! Link to the paper here Very nice to see that Haloferax can indeed catalyse reactions as whole cell organism and be […]
Catalysts (2019): “Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester”
Very well done David for bringing this paper to a close, the insolubility issue of the substrates was really problematic for flow biocatalysis and the use of small amounts of surfactants solved it much better than high percentage of organic solvents. You can read the paper here
Catalysts (2019): “Synthetic Biomimetic Coenzymes and Alcohol Dehydrogenases for Asymmetric Catalysis”
A very nice work where we collaborated with Caroline Paul in Delft to help her assessing the role of biomimetic coenzymes. Full paper here
Frontiers in Microbiology (2019): “Structural characterization of the Xi class glutathione transferase from the haloalkaliphilic archaeon Natrialba magadii”
First one of 2019! This was a nice collaboration where Jenni cloned the gene for Prof. Allocati (University of Chieti-Pescara) so they could do a full characterisation of this novel enzyme. Check it out here
Scientific Reports (2018): Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form
Very nice to finally have this work out too. Another great collaboration with Prof. Molinari in Milan, here we demonstrate the strategic role of a Phe16 (or equivalent) for the folding of transaminases. We found a native TA which had a threonine at that position and was expressed only insolubly. By replacing the T for […]
Advanced Synthesis and Catalysis (2018): Biocatalytic N‐Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis
Well done to Martina, another great paper and a fabulous nice enzyme we think we can incorporate easily in our cascades. You can find the paper here
Catalysts (2018): “Genetically Fused T4L Acts as a Shield in Covalent Enzyme Immobilisation Enhancing the Rescued Activity”
Well done to Matteo, David (first paper!) and Martina for this paper. It was an invited publication for a special issue of the journals Catalysts on “Immobilized Biocatalysts”. You can read the paper here: http://www.mdpi.com/2073-4344/8/1/40/pdf
PlosOne (2017): “Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design”
Great work for Jenni and Larah who successfully published a nice piece of research in Plos One. This was a collaborations between our group and the group of Prof. Loredano Pollegioni in Milan, so massive thanks to them also! PlosOne is open access, you can read the article without a subscription to the journal. Cassidy […]
ChemCatChem Cover and Cover Profiles are out!
We are very happy with the front cover of our article which comes out in the October issue, have a look also at the “Cover Profile” which tells you a bit about how the collaboration with Prof. Molinari started and we loved about this project (click on the red text!) 2017 ChemCatChem profiles Related Posts
ChemCatChem (2017): Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis
Another great achievement for the group. This paper was chosen for the front cover of the journal, stay tuned to see how it looks like! The article is already available online https://doi.org/10.1002/cctc.201701147