Green Chemistry (2019): “Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process”

To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here, an ultra-efficient, and sustainable enzymatic platform for the multi-gram synthesis of melatonin (and analogues) was developed. The fully-automated process integrates biocatalysis and flow chemistry, maximizes the overall yields, and reduce reaction times (to 5 minutes!) bridging the gap between lab scale and industrial production. Great work by everyone involved! Read the full paper here