ChemSusChem (2022): “Sustainable (flow)synthesis of antiviral and anticancer nucleosides by a novel purine nucleoside phosphorylase reversibly immobilized”
Chemistry- A European Journal (2021): “GPhos ligand enables the production of chiral N-arylamines in a telescoped transaminase–Buchwald-Hartwig amination cascade in the presence of excess amine donor”
A fine paper from Chris. Here he explored how we can combine transaminases and chemocatalysis, specifically looking for water-compatible Pd catalysts to synthesise arylamines. All the credits goes to him and he shares here the corresponding authorship! Chemistry- A European Journal 2021 in press (doi:10.1002/chem.202103472) Read the full paper here Related Posts
Chem Comm (2021): “Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity”
Another collaborative paper with the group of Martin Albrecht here at the DCBP, we really like to combine carbenes and natural molecules such as peptides and check out how the catalysis is affected. Matteo worked on the synthesis and David did his usual magic with molecular dynamics and simulations! A great paper to read! Chemical Communication 2021, 57, 9068 – 9071 […]
Green Chemistry (2021): “Biocatalytic access to betazole by one-pot multienzymatic system in continuous flow”
Maria successfully tackled a multi enzyme system which requires a NOX enzyme to recycle the NADH cofactor. Not a small battle when you require to maximise the air/oxygen content in a sealed system like a flow reactor. Very proud of this work! Abstract: “As an alternative to classical synthetic approaches for the production of betazole drug, a […]
ACS Sustainable Chemistry and Engineering (2021): ” Enantio-complementary continuous-flow synthesis of 2-aminobutane using covalently immobilized transaminases”
Amazing work with our collaborator Dr. Beatriz Domingues in Johnson Matthey. Chris engineered our evergreen HeWT to make it enantioselective in the synthesis of the smallest chiral amine, 2 amino butane. Well done! You can find the paper here Related Posts
J Biotech (2021): “Producing natural vanilla extract from green vanilla beans using a β-glucosidase from Alicyclobacillus acidiphilus”
Last in the trilogy of Lidia’s PhD, lovely work completed with the help of Chris where a very rare green vanilla pod was used as the substrate! The paper was accepted just before Lidia’s Phd viva, a good sign! Read the full paper here Related Posts
Bioinformatics (2021): “CapiPy: python-based GUI-application to assist in protein immobilization”
David did an amazing work in building this program. It will help in identifying possible starting points for immobilisation of enzymes, it provides in one single program very useful information particularly relevant in immobilisation on the protein structure. Valentina also was key in testing the program with as many proteins as possible. If you would like […]
Nature Catalysis (2020): “A strategic Ser/Cys exchange in the catalytic triad unlocks an acyltransferase mediated synthesis of thioesters and tertiary amides”
Martina did it again! Working together with David, they looked at how the acyltransferases we have worked with before could become an even more efficient catalyst. Find the paper here or you can access a read only version here. Related Posts
ChemBioChem (2021): “Release of soybean isoflavones using a β-Glucosidase from Alicyclobacillus herbarius”
Well done to Lidia and Chris and massive thank you to Louise Gourlay (excellent crystallographer at the University of Milan) for this great work on the extraction of isofavones from soy flour with a new glycosyl hydrolase. Abstract: β-Glucosidases are used in the food industry to hydrolyse glycosidic bonds in complex sugars, with enzymes sourced […]
ChemCatChem (2020): “Looking back: A short history of the discovery of enzymes and how they became powerful chemical tools”
Chris during the lockdown made the most of hist time by writing chapters of his thesis. When he sent me the introduction I was so very impressed by his story-telling ability and unique take on how to craft such chapter. I had no doubt we had to try and publish it. I am ever so […]