Green Chemistry (2017) : “Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata”
Great achievement for the group! Matteo, Martina and Jenni, together with our collaborators in Milan (Prof. Molinari and Dr. Tamborini) are celebrating a very nice paper on flow chemistry using our transaminase from Halomonas. Well done! The paper “Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata” is published […]
ChemCatChem (2017): Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis
Another great achievement for the group. This paper was chosen for the front cover of the journal, stay tuned to see how it looks like! The article is already available online https://doi.org/10.1002/cctc.201701147
Trends in Biotechnology (2018): “Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification”
We have a nice review which just went online, a mammoth effort between Milan, Lisbon, and Nottingham https://doi.org/10.1016/j.tibtech.2017.09.005
ACS Sustainable Chemistry & Engineering (2018): Self-sufficient flow-biocatalysis by co-immobilisation of pyridoxal 5´-phosphate and ω-transaminases onto porous carriers
Amazing work with our collaborator Fernando Lopez-Gallego in Zaragoza, delighted about this paper which we hope to be the first of many joint publications. Well done to Anabel, Martina and Susana! You can find the paper here
ChemBioChem (2019): “Transaminase-catalyzed continous synthesis of biogenic aldehydes”
Well done to Martina for securing another paper in the field of flow biocatalysis. Here we have looked at the possibility of preparing biogenic aldehydes from biological amines. Exploiting previous work we have co-immobilised the PLP cofactor generating a fully self sufficient reactor. Read the full paper here
Green Chemistry (2022): “Combined chemoenzymatic strategy for sustainable continuous synthesis of the natural product hordenine”
First paper for Stefania! To improve sustainability, safety and cost-efficiency of synthetic methodologies, biocatalysis can be a helpful ally. In this work, a novel chemoenzymatic stategy ensures the rapid synthesis of hordenine, a valuable phenolic phytochemical under mild working conditions. In a two-step cascade, the immobilized tyrosine decarboxylase from Lactobacillus brevis (LbTDC) is here coupled with the […]
ChemSusChem (2022): “Biocatalytic production of a Nylon 6 precursor from caprolactone in continuous flow”
Green Chemistry (2021): “Biocatalytic access to betazole by one-pot multienzymatic system in continuous flow”
Maria successfully tackled a multi enzyme system which requires a NOX enzyme to recycle the NADH cofactor. Not a small battle when you require to maximise the air/oxygen content in a sealed system like a flow reactor. Very proud of this work! Abstract: “As an alternative to classical synthetic approaches for the production of betazole drug, a […]
David and Ana’s paper makes the 2020 HOT Green Chemistry articles list
The work just published in Green Chemistry co-authored by Ana and David has been selected as a 2020 HOT Green Chemistry article. It is gold open access, can be freely accessed here. It is great to see the drive of the group in doing cutting edge research with dedication and true passion. Very well done! […]
Green Chemistry (2020): “Cell-free biocatalytic synthesis of pipecolic acid: a dual strategy approach and process intensification in flow”
This work was supported by the Wellcome Prime Award Fran received in 2018 through the University of Nottingham. This grant funded Ana for several month as a Post Doc in Nottingham and together with David they worked on a very nice system to produce pipe colic acid (high value molecule) from simple lysine. Liam was a fourth […]