Amino Acids (2017): Stabilization of Angiotensin-(1–7) by key substitution with a cyclic non-natural amino acid
Well done to Anita! Her work finally rewarded! This paper was the result of our collaborative work with Prof. Gallagher at Wake Forest University in North Carolina and the major stabilising effect of incorporating our non natural cyclic amino acid into the Angiotensin sequence, without loosing its anti proliferative properties is a significant step forward […]
ChemCatChem (2017): Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis
Another great achievement for the group. This paper was chosen for the front cover of the journal, stay tuned to see how it looks like! The article is already available online https://doi.org/10.1002/cctc.201701147
PlosOne (2017): “Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design”
Great work for Jenni and Larah who successfully published a nice piece of research in Plos One. This was a collaborations between our group and the group of Prof. Loredano Pollegioni in Milan, so massive thanks to them also! PlosOne is open access, you can read the article without a subscription to the journal. Cassidy […]
Catalysts (2018): “Genetically Fused T4L Acts as a Shield in Covalent Enzyme Immobilisation Enhancing the Rescued Activity”
Well done to Matteo, David (first paper!) and Martina for this paper. It was an invited publication for a special issue of the journals Catalysts on “Immobilized Biocatalysts”. You can read the paper here: http://www.mdpi.com/2073-4344/8/1/40/pdf
Advanced Synthesis and Catalysis (2018): Biocatalytic N‐Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis
Well done to Martina, another great paper and a fabulous nice enzyme we think we can incorporate easily in our cascades. You can find the paper here
Scientific Reports (2018): Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form
Very nice to finally have this work out too. Another great collaboration with Prof. Molinari in Milan, here we demonstrate the strategic role of a Phe16 (or equivalent) for the folding of transaminases. We found a native TA which had a threonine at that position and was expressed only insolubly. By replacing the T for […]
Chemical Science (2019): “Widely applicable background depletion step enables transaminase evolution through solid-phase screening”
This paper describes what appears to be an almost trivial solution to a very well known issue in microbial screening for transaminase activity. Quenching the background with a simple neutralization of the basal pyruvate presence was a stroke of genius! Well done to everyone who contributed! And by the way, we have included also the […]
David and Ana’s paper makes the 2020 HOT Green Chemistry articles list
The work just published in Green Chemistry co-authored by Ana and David has been selected as a 2020 HOT Green Chemistry article. It is gold open access, can be freely accessed here. It is great to see the drive of the group in doing cutting edge research with dedication and true passion. Very well done! […]
Green Chemistry (2019): “Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process”
To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here, an ultra-efficient, and sustainable enzymatic platform for the multi-gram synthesis of melatonin (and analogues) was developed. The fully-automated process integrates biocatalysis and flow chemistry, maximizes the […]
Chemical Science (2019): “Widely applicable background depletion step enables transaminase evolution through solid-phase screening”
This paper describes what appears to be an almost trivial solution to a very well known issue in microbial screening for transaminase activity. Quenching the background with a simple neutralization of the basal pyruvate presence was a stroke of genius! Well done to everyone who contributed! And by the way, we have included also the […]